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Cytokines: From Basic Mechanisms of Cellular Control to New Therapeutics

Book Series:  A Cold Spring Harbor Perspectives in Biology Collection
Subject Area(s):  Cell Biology

Edited by Warren J. Leonard, Bethesda MD; Robert D. Schreiber, St. Louis MO

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The Future of the Cytokine Discipline

© 2018 • 470 pages, illustrated (57 color and 4 B&W), index
Hardcover • $135 108.00
ISBN  978-1-621821-25-0
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  •     Description    
  •     Contents    
  •     Reviews    


Cytokines (e.g., interleukins and interferons) are small signaling proteins that are essential for communication between cells. They are important regulators of the immune system, helping to control lymphocyte development and function, orchestrate inflammation, and defeat microbial and viral invaders. But they also play important roles in the nervous system, embryonic development, and diseases such as cancer.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers the spectrum of cytokines that are produced and their roles in normal physiology and disease. The contributors examine the numerous cytokines and their cognate receptors, the downstream signaling mechanisms (e.g., JAK-STAT pathways) that mediate the effects of cytokines on cells, and the regulators that keep them in check (e.g., long noncoding RNAs and the SOCS and IRF protein families). These molecular interactions are discussed in the context of their physiological effects; the roles of cytokines in the development and activities of the immune system are emphasized.

The authors also explore how the actions of cytokines may be modulated for treating patients with autoimmune disorders, immunodeficiency, infections, allergies, and cancer. Thus, this volume is an indispensable reference not only for cell biologists and immunologists but for all who are interested in targeting cytokine signaling for therapeutic purposes.


The Common Cytokine Receptor γ Chain Family of Cytokines
Jian-Xin Lin and Warren J. Leonard
Role of the β Common (βc) Family of Cytokines in Health and Disease
Timothy R. Hercus, Winnie L.T. Kan, Sophie E. Broughton, Denis Tvorogov, Hayley S. Ramshaw, Jarrod J. Sandow, Tracy L. Nero, Urmi Dhagat, Emma J. Thompson, Karen S. Cheung Tung Shing, Duncan R. McKenzie, Nicholas J. Wilson, Catherine M. Owczarek, Gino Vairo, Andrew D. Nash, Vinay Tergaonkar, Timothy Hughes, Paul G. Ekert, Michael S. Samuel, Claudine S. Bonder, Michele A. Grimbaldeston, Michael W. Parker, and Angel F. Lopez
Interleukin-6 Family Cytokines
Stefan Rose-John
Interleukin (IL-6) Immunotherapy
Toshio Tanaka, Masashi Narazaki, and Tadamitsu Kishimoto
The Tumor Necrosis Factor Family: Family Conventions and Private Idiosyncrasies
David Wallach
Interleukin 17 Family Cytokines: Signaling Mechanisms, Biological Activities, and Therapeutic Implications
Leticia Monin and Sarah L. Gaffen
Interleukin (IL)-12 and IL-23 and Their Conflicting Roles in Cancer
Juming Yan, Mark J. Smyth, and Michele W.L. Teng
Targeting IL-10 Family Cytokines for the Treatment of Human Diseases
Xiaoting Wang, Kit Wong, Wenjun Ouyang, and Sascha Rutz
Responses to Cytokines and Interferons that Depend upon JAKs and STATs
George R. Stark, HyeonJoo Cheon, and Yuxin Wang
The Interferon (IFN) Class of Cytokines and the IFN Regulatory Factor (IRF) Transcription Factor Family
Hideo Negishi, Tadatsugu Taniguchi, and Hideyuki Yanai
Interferon γ and Its Important Roles in Promoting and Inhibiting Spontaneous and Therapeutic Cancer Immunity
Elise Alspach, Danielle M. Lussier, and Robert D. Schreiber
Interleukin (IL)-33 and the IL-1 Family of Cytokines—Regulators of Inflammation and Tissue Homeostasis
Ajithkumar Vasanthakumar and Axel Kallies
Inflammasome-Dependent Cytokines at the Crossroads of Health and Autoinflammatory Disease
Hanne Van Gorp, Nina Van Opdenbosch, and Mohamed Lamkanfi
Cytokines, Transcription Factors, and the Initiation of T-Cell Development
Hiroyuki Hosokawa and Ellen V. Rothenberg
Cytokines and Long Noncoding RNAs
Susan Carpenter and Katherine A. Fitzgerald
Negative Regulation of Cytokine Signaling in Immunity
Akihiko Yoshimura, Minako Ito, Shunsuke Chikuma, Takashi Akanuma, and Hiroko Nakatsukasa
T Helper Cell Differentiation, Heterogeneity, and Plasticity
Jinfang Zhu
Cytokine Signaling in the Development and Homeostasis of Regulatory T Cells
Kevin H. Toomer and Thomas R. Malek
Cytokine-Mediated Regulation of CD8 T-Cell Responses during Acute and Chronic Viral Infection
Masao Hashimoto, Se Jin Im, Koichi Araki, and Rafi Ahmed
Innate Lymphoid Cells (ILCs): Cytokine Hubs Regulating Immunity and Tissue Homeostasis
Maho Nagasawa, Hergen Spits, and Xavier Romero Ros
Development, Diversity, and Function of Dendritic Cells in Mouse and Human
David A. Anderson III, Kenneth M. Murphy, and Carlos G. Briseño
Cancer Inflammation and Cytokines
Maria Rosaria Galdiero, Gianni Marone, and Alberto Mantovani
Cytokines in Cancer Immunotherapy
Thomas A. Waldmann
The Future of the Cytokine Discipline
Joost J. Oppenheim


review:  “Cytokines, which includes 24 chapters written by researchers the world over, touches on the entire field, and is thus a timely contribution to disseminating the cytokine story. And it is a complicated story, indeed….Of course, there remain many open questions,…and…will likely be answered by someone just entering the field now, and Cytokines could give them the perspective to do just that.”
      —The Quarterly Review of Biology