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Bone: A Regulator of Physiology

Book Series:  A Cold Spring Harbor Perspectives in Medicine Collection
Subject Area(s):  Human Biology and Disease

Edited by Gerard Karsenty, Columbia University Medical Center; David T. Scadden, Harvard Medical School

Download a Free Excerpt from Bone: A Regulator of Physiology:

Regulation of Bone Metabolism by Sex Steroids

© 2018 • 232 pages, illustrated (33 color and 5 B&W), index
Hardcover •
ISBN  978-1-621822-20-2

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  •     Description    
  •     Contents    
  •     Reviews    


Bone plays far more than just a structural role in our bodies. It actively communicates with our brains, kidneys, and other organs, releasing and responding to signaling molecules that regulate biological processes such as glucose metabolism and lymphoid development. Defects in these interactions may lead to osteoporosis, multiple myeloma, and other diseases or developmental flaws.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine examines our current understanding of the dynamic interactions between bone and other organs and systems in the body and the molecules and mechanisms that mediate them. Contributors discuss endocrine factors that act on bone (e.g., parathyroid hormone and sex steroids) as well as molecules that are secreted by bone and act on other tissues (e.g., osteocalcin and FGF23). The interplay between bone and the nervous, immune, and vascular systems is explored, as is the influence of gut microbiota on bone homeostasis.

The authors also consider the diseases that result when homeostatic pathways are disrupted and how new knowledge of these pathways may be harnessed for the development of therapeutics. This volume is therefore a valuable reference for not only physiologists and endocrinologists but for all who are interested in diseases linked to the skeletal system.


Biology of Bone: The Vasculature of the Skeletal System
Emma C. Watson and Ralf H. Adams
Mechanism of Bone Mineralization
Monzur Murshed
Regulation of Bone Metabolism by Sex Steroids
Sundeep Khosla and David G. Monroe
Regulation of Bone Remodeling by Parathyroid Hormone
Marc N. Wein and Henry M. Kronenberg
Neural Regulation of Bone and Bone Marrow
Maria Maryanovich, Shoichiro Takeishi, and Paul S. Frenette
The Bone Marrow Microenvironment in Health and Myeloid Malignancy
Marta Galán-Díez, Álvaro Cuesta-Domínguez, and Stavroula Kousteni
Multiple Myeloma and Bone: The Fatal Interaction
Silvia Marino and G. David Roodman
The Biology of Bone Metastasis
Mark Esposito, Theresa Guise, and Yibin Kang
Kazuo Okamoto and Hiroshi Takayanagi
Biology of Fibroblast Growth Factor 23: From Physiology to Pathology
Marie Courbebaisse and Beate Lanske
Regulation of Energy Metabolism by Bone-Derived Hormones
Paula Mera, Mathieu Ferron, and Ioanna Mosialou
Bone Remodeling and the Microbiome
Roberto Pacifici


review:  “The internationally renowned contributing authors are experts in specific interactions between bone and other organ systems and provide clear and accessible summaries of the state-of-the-art research in their respective areas. The book is understandable to nonbone biologists, but provides depth and comprehensive references so that bone biologists are sure to learn something as well. The images are clear and detailed and will surely become the representative illustrations researchers use to explain complicated bone-system interactions.”
      —The Quarterly Review of Biology