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T-Cell Memory

Book Series:  A Cold Spring Harbor Perspectives in Biology Collection
Subject Area(s):  Developmental BiologyImmunology and VaccinesCancer Biology

Edited by David Masopust, University of Minnesota; Rafi Ahmed, Emory University

Download a Free Excerpt from T-Cell Memory:

Formation of Tissue-Resident CD8+ T-Cell Memory

© 2021 • 366 pages, illustrated (51 color and 1 B&W), index
Hardcover •
ISBN  978-1-621821-55-7

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  •     Description    
  •     Contents    
  •     Reviews    


Memory T cells are highly specific, long-lived cells that remain in the body after infection by a disease-causing agent, ready to mount a strong and rapid immune response if the same pathogen is encountered again. They also play central roles in the body's ability to develop immunity after vaccination and in protecting the body against cancer.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology reviews the arsenal of memory T-cell subtypes in the body and how they function as key components of the adaptive immune system. The contributors examine the heterogeneity and diversity of memory T-cell subtypes, how they are classified and named, and their biological characteristics—their transcriptional and metabolic features, migration patterns, life spans, and surveillance activities. The differentiation of T cells from a naive state, how they establish and maintain a primed memory state, and factors that contribute to their decline are all covered.

Multiple chapters are devoted to recent advances in understanding tissue-resident memory T cells, which provide local control against pathogens (e.g., in the lung and skin) and are particularly relevant for the development of vaccines and anticancer therapies. This volume is therefore a valuable reference for all immunologists, cell biologists, and cancer researchers wishing to understand the biology of memory T cells and how their unique properties might be exploited to improve human health.


Section I. Memory T-Cell Heterogeneity and Classification: How Should We Name Our T Cells?
Memory T-Cell Heterogeneity and Terminology
Yuki Muroyama and E. John Wherry
The Naming of Memory T-Cell Subsets
Stephen C. Jameson
How to Reliably Define Human CD8+ T-Cell Subsets: Markers Playing Tricks
Michiel C. van Aalderen, Rene A.W. van Lier, and Pleun Hombrink
Formation of Tissue-Resident CD8+ T-Cell Memory
Feline E. Dijkgraaf, Lianne Kok, and Ton N.M. Schumacher
CD8+ T-Cell Memory: The Why, the When, and the How
Stephen J. Turner, Taylah J. Bennett, and Nicole L. La Gruta
Section II. Memory T-Cell Differentiation Models
A Regenerative Perspective on Successful and Failed T-Cell Immunity
Steven L. Reiner
Motility Matters: How CD8+ T-Cell Trafficking Influences Effector and Memory Cell Differentiation
Yagmur Farsakoglu, Bryan McDonald, and Susan M. Kaech
Transcriptional Control of Cell Fate Determination in Antigen-Experienced CD8 T Cells
Shanel Tsuda and Matthew E. Pipkin
Evolving Views of Long Noncoding RNAs and Epigenomic Control of Lymphocyte State and Memory
Tasha A. Morrison, William H. Hudson, Danielle A. Chisolm, Yuka Kanno, Han-Yu Shih,
Rafi Ahmed, Jorge Henao-Mejia, Markus Hafner, and John J. O'Shea
Temporal and Epigenetic Control of Plasticity and Fate Decision during CD8+ T-Cell Memory Differentiation
Luigia Pace
Metabolic Control of Memory T-Cell Generation and Stemness
Jana L. Raynor, Nicole M. Chapman, and Hongbo Chi
A Single-Cell Perspective on Memory T-Cell Differentiation
Lorenz Kretschmer, Dirk H. Busch, and Veit R. Buchholz
Section III. Tissue Memory
Decoding Tissue-Residency: Programming and Potential of Frontline Memory T Cells
Simone L. Park and Laura K. Mackay
Divergence of Tissue-Memory T Cells: Distribution and Function-Based Classification
Shiki Takamura
Influenza-Specific Lung-Resident Memory CD8+ T Cells
Stephanie van de Wall, Vladimer P. Badovinac, and John T. Harty
Long-Lived Skin-Resident Memory T Cells Contribute to Concomitant Immunity in Cutaneous Leishmaniasis
Phillip Scott
Area under Immunosurveillance: Dedicated Roles of Memory CD8 T-Cell Subsets
Loreto Parga-Vidal and Klaas P.J.M. van Gisbergen
Section IV. Memory T-Cell Homeostasis and Durability
CD4+ Memory T-Cell Formation during Type 1 Immune Responses
Peter D. Krueger, Kevin C. Osum, and Marc K. Jenkins
Defining the Molecular Hallmarks of T-Cell Memory
Caitlin C. Zebley, Rama S. Akondy, Benjamin A. Youngblood, and Haydn T. Kissick
Homeostasis of Naive and Memory T Lymphocytes
Takeshi Kawabe, Jaeu Yi, and Jonathan Sprent
Homeostasis and Durability of T-Cell Memory—The Resting and the Restless T-Cell Memory
Andreas Radbruch, Mairi Anne McGrath, Francesco Siracusa, Ute Hoffmann, Özen Sercan-Alp, Andreas Hutloff, Koji Tokoyoda, Hyun-Dong Chang, and Jun Dong
Durable CD4 T-Cell Memory Generation Depends on Persistence of High Levels 
of Infection at an Effector Checkpoint that Determines Multiple Fates
Susan L. Swain, Michael C. Jones, Priyadharshini Devarajan, Jingya Xia, Richard W. Dutton, Tara M. Strutt, and K. Kai McKinstry


review:  “... this collection brings awareness to the current state of knowledge with regard to memory T cells and the next questions to address.”