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Bioelectronic Medicine

Book Series:  A Cold Spring Harbor Perspectives in Medicine Collection
Subject Area(s):  Human Biology and DiseaseNeurobiology

Edited by Valentin A. Pavlov, The Feinstein Institutes for Medical Research, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell; Kevin J. Tracey, The Feinstein Institutes for Medical Research, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell

Download a Free Excerpt from Bioelectronic Medicine:

Electromagnetic Regulation of Cell Activity

© 2019 • 348 pages, illustrated (73 color and 7 B&W), index
Hardcover •
ISBN  978-1-621823-02-5

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  •     Description    
  •     Contents    


Every organ in the human body is innervated by the nervous system and communicates with the brain via electrical signals. Various devices can be used to modulate these electrical signals and elicit changes in organ function with the aim of treating injury or disease. This approach is the basis of the rapidly emerging field of bioelectronic medicine, which has the potential to diagnose and treat medical conditions more precisely and effectively than ever before.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers many aspects of bioelectronic medicine, examining the neuronal pathways that are being targeted for manipulation, the electronic neuromodulation devices that are under development, and how all of this work is leading to new diagnostics and treatment options for patients. The contributors discuss how the stimulation of specific nerves (e.g., the vagus nerve) has been successfully used to treat certain conditions (e.g., rheumatoid arthritis and Crohn’s disease) and how similar strategies are being investigated as therapeutics for a multitude of gastrointestinal, cardiovascular, respiratory, and renal disorders. They consider implantable devices, magnetoelectric nanoparticles, ultrasound, optogenetic-based approaches, and electrophotonic devices as tools for acquiring, decoding, and modulating electrical signals from nerves and how they might be used to monitor and treat patients in the clinic.

The authors also discuss the ethical concerns related to the use of technologies such as these that can alter the brain. The volume is therefore an indispensable reference for neuroscientists, biomedical engineers, and physicians interested in the benefits and challenges of recording, stimulating, and blocking electrical activity in the human body.


Bioelectronic Medicine: From Preclinical Studies on the Inflammatory Reflex to New Approaches in Disease Diagnosis and Treatment
Valentin A. Pavlov, Sangeeta S. Chavan, and Kevin J. Tracey
Optogenetic Control of the Peripheral Nervous System
Rui B. Chang
Optogenetic Medicine: Synthetic Therapeutic Solutions Precision-Guided by Light
Haifeng Ye and Martin Fussenegger
Electromagnetic Regulation of Cell Activity
Sarah A. Stanley and Jeffrey M. Friedman
Recording and Decoding of Vagal Neural Signals Related to Changes in Physiological Parameters and Biomarkers of Disease
Theodoros P. Zanos
Closed-Loop Neuromodulation in Physiological and Translational Research
Stavros Zanos
Bioelectronic Approaches to Control Neuroimmune Interactions in Acute Kidney Injury
Tsuyoshi Inoue, Shinji Tanaka, Diane L. Rosin, and Mark D. Okusa
Small Heat Shock Proteins, Amyloid Fibrils, and Nicotine Stimulate a Common Immune Suppressive Pathway with Implications for Future Therapies
Jonathan B. Rothbard, Michael P. Kurnellas, Shalina S. Ousman, Sara Brownell, Jesse J. Rothbard, and Lawrence Steinman
Noninvasive Neuromodulation of Peripheral Nerve Pathways Using Ultrasound and Its Current Therapeutic Implications
Christopher Puleo and Victoria Cotero
Vagus Nerve Stimulation and the Cardiovascular System
Michael J. Capilupi, Samantha M. Kerath, and Lance B. Becker
Empirically Based Guidelines for Selecting Vagus Nerve Stimulation Parameters in Epilepsy and Heart Failure
Eric D. Musselman, Nicole A. Pelot, and Warren M. Grill
Neural Control of Inflammation: Bioelectronic Medicine in Treatment of Chronic Inflammatory Disease
Michael Eberhardson, Laura Tarnawski, Monica Centa, and Peder S. Olofsson
Harnessing the Inflammatory Reflex for the Treatment of Inflammation-Mediated Diseases
Yaakov A. Levine, Michael Faltys, and David Chernoff
Vagus Nerve Stimulation at the Interface of Brain–Gut Interactions
Bruno Bonaz, Valérie Sinniger, and Sonia Pellissier
Enteric Neuromodulation for the Gut and Beyond
Yogi A. Patel and Pankaj J. Pasricha
Use of Bioelectronics in the Gastrointestinal Tract
Larry Miller, Aydin Farajidavar, and Anil Vegesna
Microscale and Nanoscale Electrophotonic Diagnostic Devices
Kaiyu Fu, Wei Xu, Jiayun Hu, Arielle Lopez, and Paul W. Bohn
Electrical Impedance Methods in Neuromuscular Assessment: An Overview
Seward B. Rutkove and Benjamin Sanchez
Technobiology’s Enabler: The Magnetoelectric Nanoparticle
Sakhrat Khizroev
Restoring Movement in Paralysis with a Bioelectronic Neural Bypass Approach: Current State and Future Directions
Chad E. Bouton
Diabetes Technology: Monitoring, Analytics, and Optimal Control
Boris Kovatchev
Bioelectronic Medicine—Ethical Concerns
Samuel Packer, Nicholas Mercado, and Anita Haridat