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Tissue Engineering and Regenerative Medicine

Book Series:  A Cold Spring Harbor Perspectives in Medicine Collection
Subject Area(s):  Cell BiologyHuman Biology and Disease

Edited by Joseph P. Vacanti, Massachusetts General Hospital and Harvard Medical School

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© 2017 • 162 pages, illustrated (25 color), index
Hardcover •
ISBN  978-1-621821-28-1

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  •     Description    
  •     Contents    
  •     Reviews    


Tissue engineering is an interdisciplinary field in which scaffolds, cells, and biologically active molecules are used to construct body tissues and organs. The field aims to find solutions for the repair of damaged tissues and enable the production of organs for transplantation.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine surveys tools that are currently available to scientists and engineers in the field and how they have been used to fabricate physiologically appropriate tissues and organs. The contributors discuss the preparation of biologically active scaffolds that induce regenerative responses, three-dimensional bioprinting strategies to fabricate structures in preprogrammed patterns, and scaffold-free approaches using cells capable of self-assembly.

The authors also review recent advances in the fabrication of specific body structures, including the craniofacial complex, heart and blood vessels, intestine, and bone and cartilage. This book is therefore essential reading for all scientists, engineers, and physicians interested in the replacement, repair, or regeneration of human organs and tissues.


Biologic Scaffolds
Alessandra Costa, Juan Diego Naranjo, Ricardo Londono, and Stephen F. Badylak
The Self-Assembling Process and Applications in Tissue Engineering
Jennifer K. Lee, Jarrett M. Link, Jerry C.Y. Hu, and Kyriacos A. Athanasiou
Three-Dimensional Bioprinting Strategies for Tissue Engineering
Yu Shrike Zhang, Rahmi Oklu, Mehmet Remzi Dokmeci, and Ali Khademhosseini
Honing Cell and Tissue Culture Conditions for Bone and Cartilage Tissue Engineering
Johnny Lam, Esther J. Lee, Elisa C. Clark, and Antonios G. Mikos
Craniofacial Tissue Engineering
Weibo Zhang and Pamela Crotty Yelick
The Heart and Great Vessels
Ekene Onwuka, Nakesha King, Eric Heuer, and Christopher Breuer
Historical Perspective and Future Direction of Blood Vessel Developments
Sashka Dimitrievska and Laura E. Niklason
Tissue Engineering Functional Gastrointestinal Regions: The Importance of Stem and Progenitor Cells
Andrew Trecartin and Tracy Grikscheit
Tissue Engineering for Art, Design, and Other Cultural Artifacts
Oron Catts and Ionat Zurr


review:  “Overall, this is an unusual book, which will be of interest to a broad spectrum of readers, from experts in the field to novices and the general public. All of the chapters are very well written and although being scientifically precise, convey the key messages in a simple way that is easy to follow. It is a true pleasure to read this volume. It helps us understand some of the key biological principles for our tissue engineering designs, and it informs readers how important the converging, holistic approach is for the future development of the field.”
      —The Quarterly Review of Biology