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Translation Mechanisms and Control

Book Series:  A Cold Spring Harbor Perspectives in Biology Collection
Subject Area(s):  Molecular Biology

Edited by Michael B. Mathews, Rutgers - New Jersey Medical School Cancer Center; Nahum Sonenberg, McGill University; John W.B. Hershey, University of California, Davis

Download a Free Excerpt from Translation Mechanisms and Control:

Principles of Translational Control

© 2018 • 499 pages, illustrated (81 color and 3 B&W), index
Hardcover •
ISBN  978-1-621821-86-1

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  •     Description    
  •     Contents    


Translation is the process by which cells synthesize proteins. During the process, molecular machines called ribosomes use messenger RNA molecules that relay the genetic code from DNA to direct assembly of the amino acid building blocks that make up proteins. This is all tightly controlled to ensure that the correct proteins are synthesized at the appropriate time and in the quantities needed by the cell. Aberrant translation causes significant problems for cells and contributes to cancer and various neurological disorders (e.g., autism).

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology examines our current understanding of all aspects of protein synthesis and its control. The contributors describe recent insights into the fundamental steps in translation (initiation, elongation, termination, and ribosome recycling) based on high-resolution structures of the translational machinery. The signaling pathways and targets of translational control (e.g., initiation factors, mRNAs, and ribosomes) are discussed, as are the roles of riboswitches, processing bodies (P-bodies), stress granules, and various classes of RNAs (e.g., circular RNAs). Methods to study translation dynamics, including ribosome profiling, kinetic assays, and single-molecule and single-cell fluorescence imaging, are also covered.

In addition, the authors examine translational control during early embryo development, stem cell differentiation, and memory formation. The deregulation of translation in cancer and neurological disorders, as well as the development of small molecules that target translation for therapeutic purposes, is also discussed. This volume is therefore an essential reference not only for cell and molecular biologists but also for cancer biologists and others who investigate human diseases associated with dysregulation of translation.


Principles of Translational Control
John W.B. Hershey, Nahum Sonenberg, and Michael B. Mathews
Protein Synthesis and Translational Control: A Historical Perspective
Soroush Tahmasebi, Nahum Sonenberg, John W.B. Hershey, and Michael B. Mathews
Protein Synthesis Initiation in Eukaryotic Cells
William C. Merrick and Graham D. Pavitt
Translation Elongation and Recoding in Eukaryotes
Thomas E. Dever, Jonathan D. Dinman, and Rachel Green
Translation Termination and Ribosome Recycling in Eukaryotes
Christopher U.T. Hellen
Translation in Prokaryotes
Marina V. Rodnina
New Insights into Ribosome Structure and Function
Amy Jobe, Zheng Liu, Cristina Gutierrez-Vargas, and Joachim Frank
Ribosome Profiling: Global Views of Translation
Nicholas T. Ingolia, Jeffrey A. Hussmann, and Jonathan S. Weissman
Toward a Kinetic Understanding of Eukaryotic Translation
Masaaki Sokabe and Christopher S. Fraser
Single-Molecule Fluorescence Applied to Translation
Arjun Prabhakar, Elisabetta Viani Puglisi, and Joseph D. Puglisi
Fluorescence Imaging Methods to Investigate Translation in Single Cells
Jeetayu Biswas, Yang Liu, Robert H. Singer, and Bin Wu
The Epitranscriptome in Translation Regulation
Eyal Peer, Sharon Moshitch-Moshkovitz, Gideon Rechavi, and Dan Dominissini
Roles of Long Noncoding RNAs and Circular RNAs in Translation
Marina Chekulaeva and Nikolaus Rajewsky
Noncanonical Translation Initiation in Eukaryotes
Thaddaeus Kwan and Sunnie R. Thompson
Repeat-Associated Non-ATG Translation in Neurological Diseases
Tao Zu, Amrutha Pattamatta, and Laura P.W. Ranum
The Interplay between the RNA Decay and Translation Machinery in Eukaryotes
Adam M. Heck and Jeffrey Wilusz
Nonsense-Mediated mRNA Decay Begins Where Translation Ends
Evangelos D. Karousis and Oliver Mühlemann
Riboswitches and Translation Control
Ronald R. Breaker
Mechanistic Insights into MicroRNA-Mediated Gene Silencing
Thomas F. Duchaine and Marc R. Fabian
Stress Granules and Processing Bodies in Translational Control
Pavel Ivanov, Nancy Kedersha, and Paul Anderson
Role of eIF2α Kinases in Translational Control and Adaptation to Cellular Stress
Ronald C. Wek
Phosphorylation and Signal Transduction Pathways in Translational Control
Christopher G. Proud
Translational Control in Cancer
Nathaniel Robichaud, Nahum Sonenberg, Davide Ruggero, and Robert J. Schneider
Translational Control during Developmental Transitions
Felipe Karam Teixeira and Ruth Lehmann
Translational Control in the Brain in Health and Disease
Wayne S. Sossin and Mauro Costa-Mattioli
Translational Control in Virus-Infected Cells
Noam Stern-Ginossar, Sunnie R. Thompson, Michael B. Mathews, and Ian Mohr
Therapeutic Opportunities in Eukaryotic Translation
Jennifer Chu and Jerry Pelletier