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Calcium Signaling, Second Edition

Subject Area(s):  Cell BiologyBiochemistry

Edited by Geert Bultynck, KU Leuven; Martin D. Bootman, The Open University; Michael J. Berridge, The Babraham Institute; Grace E. Stutzmann, Rosalind Franklin University / The Chicago Medical School

Download a Free Excerpt from Calcium Signaling, Second Edition:

Fundamentals of Cellular Calcium Signaling: A Primer

© 2019 • 568 pages, illustrated (108 color and 2 B&W), index
Hardcover •
ISBN  978-1-621822-92-9

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  •     Description    
  •     Contents    
  •     Reviews    


Calcium signals—rapid changes in calcium ion concentration—are carefully orchestrated by a suite of proteins that transport and bind to calcium ions inside cells. These signals influence virtually all aspects of animal development and physiology, from fertilization and cell differentiation to muscle contraction and nerve impulses. Aberrant calcium signaling is associated with various pathologies (e.g., cancer and neurodegeneration) as well as aging.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology provides a comprehensive update on major facets of calcium signaling. The contributors discuss the components and activities of the various calcium-sequestering organelles inside cells, the dynamic interactions that lead to spatiotemporally distinct signals in different circumstances, and the downstream effector mechanisms that translate the signals into biological outcomes. Recent advances in the field (e.g., structural insights into the functions of certain calcium channels) are emphasized throughout.

The authors also discuss normal and perturbed calcium signaling during fertilization, development, physiology, regeneration, aging, and disease. This volume is therefore an indispensable reference for biochemists, cell and developmental biologists, and physiologists seeking a comprehensive treatment of calcium signaling.


Fundamentals of Cellular Calcium Signaling: A Primer
Martin D. Bootman and Geert Bultynck
Transient Receptor Potential Channels and Calcium Signaling
Laura Vangeel and Thomas Voets
Store-Operated Calcium Channels: From Function to Structure and Back Again
Richard Lewis
The Endoplasmic Reticulum–Plasma Membrane Junction: A Hub for Agonist Regulation of Ca2+ Entry
Hwei Ling Ong and Indu Suresh Ambudkar
Signaling through Ca2+ Microdomains from Store-Operated CRAC Channels
Pradeep Barak and Anant B. Parekh
Structure and Function of IP3 Receptors
David L. Prole and Colin W. Taylor
NAADP Receptors
Antony Galione
Bcl-2-Protein Family as Modulators of IP3 Receptors and Other Organellar Ca2+ Channels
Hristina Ivanova, Tim Vervliet, Giovanni Monaco, Lara E. Terry, Nicolas Rosa, Mariah R. Baker, Jan B. Parys, Irina I. Serysheva, David I. Yule, and Geert Bultynck
Primary Active Ca2+ Transport Systems in Health and Disease
Jialin Chen, Aljona Sitsel, Veronick Benoy, M. Rosario Sepúlveda, and Peter Vangheluwe
Cytoplasmic and Mitochondrial Calcium Signaling: A Two-Way Relationship
Benjamin Wacquier, Laurent Combettes, and Geneviève Dupont
Lysosomal Ca2+ Homeostasis and Signaling in Health and Disease
Emyr Lloyd-Evans and Helen Waller-Evans
Cytosolic Ca2+ Buffers Are Inherently Ca2+ Signal Modulators
Beat Schwaller
Organellar Calcium Handling in the Cellular Reticular Network
Wen-An Wang, Luis B. Agellon, and Marek Michalak
Structural Insights into the Regulation of Ca2+/Calmodulin-Dependent Protein Kinase II (CaMKII)
Moitrayee Bhattacharyya, Deepti Karandur, and John Kuriyan
Calcium Sensors in Neuronal Function and Dysfunction
Robert D. Burgoyne, Nordine Helassa, Hannah V. McCue, and Lee P. Haynes
Identifying New Substrates and Functions for an Old Enzyme: Calcineurin
Jagoree Roy and Martha S. Cyert
Ca2+ Signaling and Homeostasis in Mammalian Oocytes and Eggs
Takuya Wakai, Aujan Mehregan, and Rafael A. Fissore
Role of Two-Pore Channels in Embryonic Development and Cellular Differentiation
Sarah E. Webb, Jeffrey J. Kelu, and Andrew L. Miller
Functional Consequences of Calcium-Dependent Synapse-to-Nucleus Communication: Focus on Transcription-Dependent Metabolic Plasticity
Anna M. Hagenston, Hilmar Bading, and Carlos Bas-Orth
Calcium Signaling in Cardiomyocyte Function
Guillaume Gilbert, Kateryna Demydenko, Eef Dries, Rosa Doñate Puertas, Xin Jin, Karin Sipido, and H. Llewelyn Roderick
Ca2+ Signaling in Exocrine Cells
Malini Ahuja, Woo Young Chung, Wei-Yin Lin, Beth A. McNally, and Shmuel Muallem
Ca2+ Signaling and Regeneration
Jonathan S. Marchant
Creating a New Cancer Therapeutic Agent by Targeting the Interaction between Bcl-2 and IP3 Receptors
Clark W. Distelhorst and Martin D. Bootman
The Calcium-Signaling Toolkit in Cancer: Remodeling and Targeting
Sarah J. Roberts-Thomson, Silke B. Chalmers, and Gregory R. Monteith
Calcium-Handling Defects and Neurodegenerative Disease
Sean Schrank, Nikki Barrington, and Grace E. Stutzmann
Calcium Signaling and Tissue Calcification
Diane Proudfoot
Astroglial Calcium Signaling in Aging and Alzheimer’s Disease
Alexei Verkhratsky


review:  “This second edition is impressive for both the breadth of coverage and the consistent quality of the chapters, each of which is authored by one or more different topic experts. While providing excellent coverage of the detailed molecular mechanisms by which calcium is stored, trafficked, and influences sets of downstream target proteins, this book also includes several chapters on the medical impacts of aberrant calcium signaling.... In so doing, the book provides a rich biomedical context for an appreciation of its basic research content.... a collection of chapters that are clear, concise, and informative.”
      —Doody's Review of Books