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The Endoplasmic Reticulum

Subject Area(s):  Developmental BiologyCell BiologyProteins and ProteomicsMolecular Biology

Edited by Susan Ferro-Novick, University of California, San Diego; Tom A. Rapoport, Harvard Medical School; Randy Schekman, University of California at Berkeley

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© 2013 • 336 pp., illus (61 4C, 9 B&W), index
Hardcover •
ISBN  978-1-936113-82-8

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The endoplasmic reticulum (ER) is an extensive network of membranes that folds, modifies, and transports proteins in eukaryotic cells. It also manufactures lipids and interacts extensively with other organelles, playing essential roles in cell growth and homeostasis.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers all aspects of ER morphology and function, as well as its interactions with the nucleus, Golgi, and mitochondria. Contributors examine how proteins translocate across the ER membrane, the processes that occur inside the ER lumen (e.g., folding, glycosylation, and disulfide bond formation), and how the proteins are packaged into vesicles and transported to the Golgi. They also review quality-control mechanisms that are employed by the ER to detect and eliminate misfolded or unassembled proteins. Lipid synthesis and transport are also discussed.

This volume covers not only the biochemistry and cell biology of the ER, but also ER stress, metabolism, and the role of the ER in viral replication. Thus, it is an essential reference for cell biologists, physiologists, and pathologists interested in understanding the numerous functions of the ER.


Endoplasmic Reticulum Stress Sensing in the Unfolded Protein Response
Brooke M. Gardner, David Pincus, Katja Gotthardt, Ciara M. Gallagher, and Peter Walter
Protein Folding Homeostasis in the Endoplasmic Reticulum and Nutritional Regulation
David Ron and Heather P. Harding
The Mammalian ERAD System
James A. Olzmann, Ron R. Kopito, and John C. Christianson
The ERAD Pathways of Budding Yeast
Guillaume Thibault and Davis T.W. Ng
Protein Folding in the Endoplasmic Reticulum
Ineke Braakman and Daniel N. Hebert
Disulfide Bond Formation in the Mammalian Endoplasmic Reticulum
Neil J. Bulleid
Endoplasmic Reticulum Structure and Interconnections with Organelles
Amber R. English and Gia K. Voeltz
Lipid Transport between the Endoplasmic Reticulum and Mitochondria
Vid V. Flis and Günther Daum
The Role of the Endoplasmic Reticulum in Peroxisome Biogenesis
Lazar Dimitrov, Sheung Kwan Lam, and Randy Schekman
How Viruses Use the Endoplasmic Reticulum for Entry, Replication, and Assembly
Takamasa Inoue and Billy Tsai
The Contribution of Systematic Approaches to Characterizing the Proteins and Functions of the Endoplasmic Reticulum
Maya Schuldiner and Jonathan S. Weissman
Cell Biology of the ER and the Golgi Apparatus through Proteomics
Jeffrey Smirle, Catherine E. Au, Michael Jain, Kurt Dejgaard, Tommy Nilsson, and John J. Bergeron
Nonvesicular Lipid Transfer from the Endoplasmic Reticulum
Sima Lev
Sphingolipid Homeostasis in the Endoplasmic Reticulum and Beyond
David K. Breslow
ER Targeting and Insertion of Tail-Anchored Membrane Proteins by the GET Pathway
Vladimir Denic, Volker Dötsch, and Irmgard Sinning
Protein Translocation across the Rough Endoplasmic Reticulum
Elisabet C. Mandon, Steven F. Truemen, and Reid Gilmore
N-linked Protein Glycosylation in the Endoplasmic Reticulum
Jörg Breitling and Markus Aebi
The Highly Conserved COPII Coat Complex Sorts Cargo from the ER and Targets it to the Golgi
Christopher Lord, Susan Ferro-Novick, and Elizabeth A. Miller
Functional Insights from Studies on the Structure of the Nuclear Pore and Coat Protein Complexes
Thomas Schwartz
Expanding Proteostasis by Membrane Trafficking Networks
Darren M. Hutt and William E. Balch
Retrograde Traffic from the Golgi to the Endoplasmic Reticulum
Anne Spang

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