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Human Fungal Pathogens

Book Series:  A Cold Spring Harbor Perspectives in Medicine Collection
Subject Area(s):  Human Biology and DiseaseMicrobiology

Edited by Arturo Casadevall, Albert Einstein College of Medicine of Yeshiva University; Aaron P. Mitchell, Carnegie Mellon University; Judith Berman, Tel Aviv University; Kyung J. Kwon-Chung, National Institute of Allergy and Infectious Diseases; John R. Perfect, Duke University Mycology Research Unit; Joseph Heitman, Duke University Medical Center

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Preface and Contents
The Spectrum of Fungi That Infects Humans

© 2015 • 577 pages, illustrated (46 color, 17 B&W), index
Hardcover •
ISBN  978-1-621820-75-8

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  •     Description    
  •     Contents    


Some yeasts and molds that are common in the environment can infect humans and cause a range of diseases, from superficial (e.g., athlete’s foot) to severe (e.g., cryptococcal meningitis). These pathogenic fungi pose a particular threat to immunocompromised individuals, such as those living with HIV/AIDS, and are becoming a leading cause of morbidity and mortality worldwide.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine provides a comprehensive review of the biology and diseases of fungal pathogens. Contributors examine their life cycles, nutritional and metabolic requirements, and morphological characteristics, as well as their interactions with humans—their modes of dissemination and penetration, the mechanisms they use to evade the immune system, and their effects on target organs. Specific chapters are devoted to the major disease-causing fungi, such as Candida, Aspergillus, and Cryptococcus species. The ecology, evolution, and epidemiology of human fungal pathogens are also explored.

This volume includes discussions about options for diagnosing and treating fungal infections, as well as challenges presented by emerging drug-resistant strains. It is therefore an essential reference for all fungal biologists and medical professionals who wish to understand and manage these difficult pathogens.


The Spectrum of Fungi That Infects Humans
Julia R. Köhler, Arturo Casadevall, and John Perfect
Evolutionary Perspectives on Human Fungal Pathogens
John W. Taylor
Sexual Reproduction of Human Fungal Pathogens
Joseph Heitman, Dee A. Carter, Paul S. Dyer, and David R. Soll
Functional Profiling of Human Fungal Pathogen Genomes
Alexi I. Goranov and Hiten D. Madhani
Rapid Mechanisms for Generating Genome Diversity: Whole Ploidy Shifts, Aneuploidy, and Loss of Heterozygosity
Richard J. Bennett, Anja Forche, and Judith Berman
Adaptive Immunity to Fungi
Akash Verma, Marcel Wüthrich, George Deepe, and Bruce Klein
Innate Defense against Fungal Pathogens
Rebecca A. Drummond, Sarah L. Gaffen, Amy G. Hise, and Gordon D. Brown
Mendelian Genetics of Human Susceptibility to Fungal Infection
Michail S. Lionakis, Mihai G. Netea, and Steven M. Holland
Fungal Biofilms, Drug Resistance, and Recurrent Infection
Jigar V. Desai, Aaron P. Mitchell, and David R. Andes
Fungal Pathogens: Survival and Replication within Macrophages
Andrew S. Gilbert, Robert T. Wheeler, and Robin C. May
Fungal Morphogenesis
Xiaorong Lin, J. Andrew Alspaugh, Haoping Liu, and Steven Harris
Host Cell Invasion by Medically Important Fungi
Donald C. Sheppard and Scott G. Filler
Metabolism in Fungal Pathogenesis
Iuliana V. Ene, Sascha Brunke, Alistair J.P. Brown, and Bernhard Hube
Fungal Diagnostics
Thomas R. Kozel and Brian Wickes
Antifungal Drug Development: Challenges, Unmet Clinical Needs, and New Approaches
Terry Roemer and Damian J. Krysan
Fungal Vaccines and Immunotherapeutics
Evelyn Santos and Stuart M. Levitz
Antifungal Pharmacokinetics and Pharmacodynamics
Alexander J. Lepak and David R. Andes
Treatment Principles for the Management of Mold Infections
Dimitrios P. Kontoyiannis and Russell E. Lewis
Treatment Principles for Candida and Cryptococcus
Laura C. Whitney and Tihana Bicanic
Antifungal Clinical Trials and Guidelines: What We Know and Do Not Know
Peter G. Pappas
Mechanisms of Antifungal Drug Resistance
Leah E. Cowen, Dominique Sanglard, Susan J. Howard, P. David Rogers, and David S. Perlin
Cryptococcus neoformans and Cryptococcus gattii,, the Etiologic Agents of Cryptococcosis
Kyung J. Kwon-Chung, James A. Fraser, Tamara L. Doering, Zhuo Wang, Guilhem Janbon, Alexander Idnurm, and Yong-Sun Bahn
The Candida Pathogenic Species Complex
Siobhán A. Turner and Geraldine Butler
Aspergillus fumigatus and Related Species
Janyce A. Sugui, Kyung J. Kwon-Chung, Praveen Juvvadi, Jean-Paul Latgé, and William J. Steinbach
Thermally Dimorphic Human Fungal Pathogens—Polyphyletic Pathogens with a Convergent Pathogenicity Trait
Anita Sil and Alex Andrianopoulos
Fungi on the Skin: Dermatophytes and Malassezia
Theodore C. White, Keisha Findley, Thomas L. Dawson, Jr., Annika Scheynius, Teun Boekhout, Christina A. Cuomo, Jun Xu, and Charles W. Saunders
Human Fungal Pathogens of Mucorales and Entomophthorales
Leonel Mendoza, Raquel Vilela, Kerstin Voelz, Ashraf S. Ibrahim, Kerstin Voigt, and Soo Chan Lee
Black Molds and Melanized Yeasts Pathogenic to Humans
Anuradha Chowdhary, John Perfect, and G. Sybren de Hoog
Francis Gigliotti, Andrew H. Limper, and Terry Wright
The Human Mycobiome
Patrick C. Seed