Contents

Preliminary

1. The Pathogenesis of Type 1 Diabetes

Kevan C. Herold and Jeffrey P. Krischer

2. Environmental Factors in Type 1 Diabetes

Heikki Hyöty, Jutta E. Laiho, and Suvi M. Virtanen

3. Breakdown and Repair of Peripheral Immune Tolerance in Type 1 Diabetes

Gerald T. Nepom

4. Monogenic Type 1 Diabetes: A High Yield Pool in Which to Discover New Mechanisms and Candidate Therapeutics for Type 1 Diabetes

Chester Chamberlain, Mike German, Lou Phillipson, and Mark S. Anderson

5. Advancing Animal Models of Human Type 1 Diabetes

David V. Serreze, Jennifer R. Dwyer, and Jeremy J. Racine

6. Cross-Talk Between β Cells and Immune Cells: What We Know, What We Think We Know, and What We Should Learn

Fatoumata Samassa, Capucine Holtzmann, and Roberto Mallone

7. Inflammatory β-Cell Stress and Immune Surveillance in Type 1 Diabetes

Anil Bhushan and Peter J. Thompson

8. The Chicken or the Egg Dilemma: Understanding the Interplay between the Immune System and the β Cell in Type 1 Diabetes

Maria Skjøtt Hansen, Pravil Pokharel, Jon Piganelli, and Lori Sussel

9. The Human Pancreas in Type 1 Diabetes: Lessons Learned from the Network of Pancreatic Organ Donors with Diabetes

Irina Kusmartseva, Amanda Posgai, Mingder Yang, Richard Oram, Mark Atkinson, Alberto Pugliese, and Carmella Evans-Molina

10. The Role of B Lymphocytes in Type 1 Diabetes

Mia J. Smith, Joanne Boldison, and F. Susan Wong

11. Innate Immunity in Type 1 Diabetes

Léo Bertrand, Alexander V. Chervonsky, and Agnès Lehuen

12. T Cell Differentiation in Autoimmune Type 1 Diabetes

Andrea Schietinger, Ian McBain, Katrina M. Hawley, and Svetlana Miakicheva

13. Genetics and Epigenetics of Type 1 Diabetes Self-Reactive T Cells

Tae Gun Kang and Benjamin Youngblood

14. Epitope Hierarchy in Type 1 Diabetes Pathogenesis

Thomas Delong and Maki Nakayama

15. Integrating Omics into Functional Biomarkers of Type 1 Diabetes

S. Alice Long and Peter S. Linsley

16. Checkpoint Inhibitor-Induced Autoimmune Diabetes: An Autoinflammatory Disease

Zoe Quandt, Ana Perdigoto, Mark S. Anderson, and Kevan C. Herold

17. Rebalancing the Immune System to Treat Type 1 Diabetes

Yannick D. Muller, Patrick Ho, Jeffrey A. Bluestone, Qizhi Tang

18. Clinical Immunologic Interventions for the Treatment of Type 1 Diabetes: Challenges, Choice and Timing of Immunomodulators

Danijela Tatovic and Colin Dayan

19. Autoantigen-Specific Immunotherapies for the Prevention and Treatment of Type 1 Diabetes

Mark Peakman and Pere Santamaria

20. The Teplizumab Saga: The Challenge of Not Getting Lost in Clinical Translation

Lucienne Chatenoud, Kevan C. Herold, Jean-François Bach, and Jeffrey A. Bluestone

21. Advances in Islet Transplantation and the Future of Stem Cell–Derived Islets to Treat Diabetes

Timothy J. Kieffer, Corinne A. Hoesli, and A.M. James Shapiro

Index