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A Cure Within: Scientists Unleashing the Immune System to Kill Cancer

Subject Area(s):  Immunology and VaccinesDiseasesCancer Biology

By Neil Canavan

Download a Free Excerpt from A Cure Within: Scientists Unleashing the Immune System to Kill Cancer:

Chapter 1: James Allison

© 2018 • 298 pages, illustrated (56 B&W), glossary, index
Hardcover • $24 19.20
ISBN  978-1-621822-17-2
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The way we treat cancer is about to change forever. This revolution—and it is precisely that—was sparked not by the invention of a new drug, but by the evolution of an entirely new way of thinking about and managing cancer. Going forward, doctors will not use pharmaceuticals to attack tumors—not directly. Rather, the oncologist will treat the patient's immune system with a drug, and then the patient will treat the tumor.

Based entirely on interviews with the investigators, this book is the story of the immuno-oncology pioneers. It's a story of failure, resurrection, and success. It's a story about science, it's a story about discovery, and intuition, and cunning. It's a peek into the lives and thoughts of some of the most gifted medical scientists on the planet.

This is not a textbook. This is a life book. This technology will save/is saving lives, and the book celebrates the living, breathing, thinking, charming, arrogant, funny, obstinate, amazing human beings who are making immuno-oncology happen.

“The stories and lives shared in this book show readers the decades of devotion and passion it takes to imagine a better world and then make it happen. If this book motivates even one more similarly talented and visionary investigator to deliver on their promise it would be a wonderful success.”

—Clifford A. Hudis, MD, FACP, FASCO
Chief Executive Officer, American Society of Clinical Oncology


Foreword, by Jill O’Donnell-Tormey
1. James Allison
2. Jedd Wolchok
3. Axel Hoos
4. Tasuku Honjo
5. Gordon Freeman
6. Suzanne L. Topalian
SECTION III: Immune Surveillance
7. Robert Schreiber, Cancer Immunoediting
SECTION IV: Vaccines
8. Drew Pardoll
9. Elizabeth Jaffee
SECTION V: Foundational Discoveries, Proof of Concept
10. Ralph Steinman, Dendritic Cells
11. Tak Mak, T-Cell Receptor (TCR)
12. Philip Greenberg, Adoptive Cell Therapy (ACT)
13. Steven Rosenberg, Interleukin-2 (IL-2)
SECTION VI: Chimeric Antigen Receptor–T Cells (CAR-Ts)
14. Zelig Eshhar
15. Patrick Hwu
16. Carl June
17. Michel Sadelain
SECTION VII: Business at the Bench: One Protein, One Virus
18. Patrick Baeuerle, Bispecific Antibodies
19. Robert Coffin, Oncolytics
SECTION VIII: T Regulatory Cells (Tregs)
20. Shimon Sakaguchi
21. Jeff Bluestone
SECTION IX: Cells and Signals: Good and Bad
22. David Munn, Indoleamine 2,3-Dioxygenase (IDO) (Signal)
23. Dmitry Gabrilovich, Myeloid-Derived Suppressor Cells (MDSCs) (Cell)
24. Tom Gajewski, Stimulator of Interferon Genes (STING) (Signal)
25. Laurence Zitvogel, Microbiome (Cell)