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Cancer Metabolism: Historical Landmarks, New Concepts, and Opportunities


Book Series:  A Cold Spring Harbor Perspectives in Medicine Collection
Subject Area(s):  Cell BiologyCancer Biology

Edited by Navdeep S. Chandel, Northwestern University; Karen H. Vousden, The Francis Crick Institute; Ralph J. DeBerardinis, UT Southwestern Medical Center

© 2025 • 300 pages (approx.), illustrated (color), index
Hardcover • $79
ISBN  978-1-621824-70-1

  •     Description    
  •     Contents    

Description

Cancer cells often display metabolic changes that distinguish them from normal cells in the body. Their preference for glycolysis over aerobic respiration even in the presence of oxygen was first observed over a century ago; however, it is only over the past two decades that researchers have begun to characterize all the pathways involved and investigate the therapeutic possibilities.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine reviews our understanding of the diversity of metabolic changes seen in cancer cells and their roles in sustaining tumor survival and proliferation. The contributors cover the new technologies being used to monitor metabolism in cells, the Warburg effect and the importance of mitochondria, metabolic signaling, and the importance of redox reactions and antioxidants. Other chapters examine the role of the tumor microenvironment, metal ions, and the immune system.

The book also discusses the role of diet and how studies of patients are revealing how metabolic reprogramming occurs. It will thus be of interest not only to biochemists and oncologists but to all biologists interested in how the behavior of cells is regulated and coordinated.

Contents

Preface
Cancer Metabolism Historical Perspectives: A Chronicle of Controversies and Consensus
Chi V. Dang
Imaging Tumor Metabolism
Thomas Ruan and Kayvan R. Keshari
Technologies for Decoding Cancer Metabolism with Spatial Resolution
Walter W. Chen, Michael E. Pacold, David M. Sabatini, and Naama Kanarek
Oncogenic Control of Metabolism
Natalya N. Pavlova and Craig B. Thompson
Lessons Learned from Cancer Metabolism for Physiology and Disease
Sydney L. Campbell and Heather R. Christofk
Growth Signaling Networks Orchestrate Cancer Metabolic Networks
Brendan D. Manning and Christian C. Dibble
Metabolic Signaling in Cancer
Laura V. Pinheiro, Pedro Costa-Pinheiro, and Kathryn E. Wellen
Understanding the Warburg Effect in Cancer
Zhaoqi Li, Muhammad Bin Munim, Daniel A. Sharygin, Brooke J. Bevis, and Matthew G. Vander Heiden
Mitochondria and Cancer
Timothy C. Kenny and Kıvanç Birsoy
Isocitrate Dehydrogenase Mutations in Cancer: Mechanisms of Transformation and Metabolic Liability
Kathryn Gunn and Julie-Aurore Losman
Knowledge-Based Therapeutics for TCA Cycle-Deficient Cancers
Daniel Peled, Ruth Casey, and Eyal Gottlieb
Interactions of Fatty Acid and Cholesterol Metabolism with Cellular Stress Response Pathways in Cancer
Alina M. Winkelkotte, Kamal Al-Shami, Adriano B. Chaves-Filho, Felix C.E. Vogel, and Almut Schulze
From the Inside Out: Exposing the Roles of Urea Cycle Enzymes in Tumors and Their Micro and Macro Environments
Emma Hajaj, Sabina Pozzi, and Ayelet Erez
Tracing the Diverse Paths of One-Carbon Metabolism in Cancer and Beyond
Esther W. Lim and Christian M. Metallo
Iron, Copper, and Selenium: Cancer’s Thing for Redox Bling
Erdem M. Terzi and Richard Possemato
The Complex Roles of Redox and Antioxidant Biology in Cancer
Makiko Hayashi, Keito Okazaki, Thales Papgiannakopoulos, and Hozumi Motohashi
The Role of Stroma in Cancer Metabolism
Alec C. Kimmelman and Mara H. Sherman
Cancer Metabolism Under Limiting Oxygen Conditions
Laura C. Kim, Nicholas P. Lesner, and M. Celeste Simon
Role of Tumor Cell Intrinsic and Host Autophagy in Cancer
Jessie Yanxiang Guo and Eileen White
Immunometabolic Maladaptations to the Tumor Microenvironment
Emma S. Hathaway, Erin Q. Jennings, and Jeffrey C. Rathmell
Diet and Cancer Metabolism
Jason W. Locasale, Marcus D. Goncalves, Maira Di Tano, and Guilermo Burgos-Barragan
Metabolic Reprogramming in Human Cancer Patients and Patient-Derived Models
Teresa W-M Fan, Richard M. Higashi, and Andrew N. Lane
Cancer Metabolism: Aspirations for the Coming Decade
Ralph J. DeBerardinis, Karen H. Vousden, and Navdeep S. Chandel
Index