Size Control in Biology: From Organelles to Organisms

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Click to Enlarge				Size Control in Biology: From Organelles to Organisms Book Series: A Cold Spring Harbor Perspectives in Biology Collection Subject Area(s): Developmental Biology; Cell Biology Edited by Rebecca Heald, University of California, Berkeley; Iswar K. Hariharan, University of California, Berkeley; David B. Wake, University of California, Berkeley *Download a Free Excerpt from Size Control in Biology: From Organelles to Organisms:* Preface Index

				© 2015 • 318 pages, illustrated (54 color, 4 B&W), index Hardcover • ~~$135~~ 108.00 ISBN 978-1-621820-72-7 You save: 20% You will receive free shipping on this item at checkout. Free shipping offer applies to direct website purchases by individual U.S. and Canada customers only. This title also available in: Paperback

Description Contents Related Titles Description Size is a primary feature of living things. From the egg to adult, the various organs, tissues, cells, and subcellular structures that make up an organism achieve appropriate sizes so that they effectively fit and function together. The misregulation of this growth can lead to diseases such as cancer. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology examines our current understanding of the intrinsic and extrinsic mechanisms that precisely regulate the sizes of biological structures so that they can function efficiently in their cellular, organismal, or ecological context. Contributors discuss the genetic, hormonal, and environmental inputs that trigger cells to grow, divide, or die, the various signaling pathways involved, and how these determine the final body size of an organism and the proportions of its component tissues and organs. Size-sensing mechanisms that enable cells to maintain their optimal sizes are reviewed, as are the scaling mechanisms that organelles use to adjust their sizes in response to changes in cell size. Examples from across the tree of life—from bacteria to humans—are provided. The authors also describe the mysteries that still remain about cell size and its control, including the nature of the intriguing relationship between nuclear DNA content and cell size. This volume will therefore be fascinating reading for all cell, developmental, and evolutionary biologists. Contents Preface Growing an Embryo from a Single Cell: A Hurdle in Animal Life Patrick H. O’Farrell The Systemic Control of Growth Laura Boulan, Marco Milán, and Pierre Léopold Indeterminate Growth: Could It Represent the Ancestral Condition? Iswar K. Hariharan, David B. Wake, and Marvalee H. Wake Biological Scaling Problems and Solutions in Amphibians Daniel L. Levy and Rebecca Heald Organ-Size Regulation in Mammals Alfredo I. Penzo-Méndez and Ben Z. Stanger Size Control in Plants—Lessons from Leaves and Flowers Hjördis Czesnick and Michael Lenhard Control of Organ Growth by Patterning and Hippo Signaling in Drosophila Kenneth D. Irvine and Kieran F. Harvey Mechanical Forces and Growth in Animal Tissues Loïc LeGoff and Thomas Lecuit The Influence of Genome and Cell Size on Brain Morphology in Amphibians Gerhard Roth and Wolfgang Walkowiak A Phyletic Perspective on Cell Growth Karl J. Niklas Genome Biology and the Evolution of Cell-Size Diversity Rachel Lockridge Mueller Cell-Size Control Amanda A. Amodeo and Jan M. Skotheim Small but Mighty: Cell Size and Bacteria Petra Anne Levin and Esther R. Angert The Opposing Actions of Target of Rapamycin and AMP-Activated Protein Kinase in Cell Growth Control Sravanth K. Hindupur, Asier González, and Michael N. Hall Nuclear DNA Content Varies with Cell Size across Human Cell Types James F. Gillooly, Andrew Hein, and Rachel Damiani Subcellular Size Wallace F. Marshall Intracellular Scaling Mechanisms Simone Reber and Nathan W. Goehring Size Scaling of Microtubule Assemblies in Early Xenopus Embryos Timothy J. Mitchison, Keisuke Ishihara, Phuong Nguyen, and Martin Wühr Index Related Titles Size Control in Biology: From Organelles to Organisms [Paperback]