Epilepsy: The Biology of a Spectrum Disorder

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Click to Enlarge				Epilepsy: The Biology of a Spectrum Disorder Book Series: A Cold Spring Harbor Perspectives in Medicine Collection Subject Area(s): Human Biology and Disease; Neurobiology Edited by Jeffrey L. Noebels, Baylor College of Medicine; Gregory L. Holmes, University of Vermont College of Medicine *Download a Free Excerpt from Epilepsy: The Biology of a Spectrum Disorder:* Preface

				© 2016 • 459 pages, illustrated (43 color, 17 B&W), index Paperback • ~~$79~~ 55.30 ISBN 978-1-621821-50-2 You save: 30% You will receive free shipping on this item at checkout. Free shipping offer applies to direct website purchases by individual U.S. and Canada customers only. This title also available in: Hardcover

Description Contents Related Titles Description Epilepsy is due to abnormal signaling of neurons in the brain that can cause seizures. It is a common condition, affecting at least 3% of individuals at some point during their life. The seizures are difficult to predict and, in a significant fraction of patients, refractory to current medical interventions. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine includes contributions covering all aspects of epilepsy, its causes, pathophysiology, clinical characteristics, comorbidities, and treatment. Contributors discuss the genetic, developmental, and environmental triggers of recurrent seizures; molecular changes (e.g., epigenetic modifications) that are associated with epileptogenesis; and the aberrant ion channels and neuronal networks involved. Clinical aspects of the disease (diagnosis, classification, and treatments) are reviewed, as are common comorbidities (e.g., depression and cognitive disorders). Recent advances in drug development and surgical techniques aimed at reducing the morbidity and mortality of patients with epilepsy are also described. The authors highlight current challenges in the field of epilepsy, with the goal of assisting others in formulating relevant research questions. This volume is therefore a vital reference not only for scientists and clinicians currently working in the field, but for all neuroscientists seeking to explore new research directions. Contents Preface Epilepsy: A Spectrum Disorder Joseph I. Sirven Seizures and Epilepsy: An Overview for Neuroscientists Carl E. Stafstrom and Lionel Carmant Status Epilepticus Syndi Seinfeld, Howard P. Goodkin, and Shlomo Shinnar Epileptogenesis Asia Pitkänen, Katarzyna Kukasiuk, F. Edward Dudek, and Kevin J. Staley Epigenetics and Epilepsy David C. Henshall and Katja Kobow Initiation, Propagation, and Termination of Partial (Focal) Seizures Marco de Curtis and Massimo Avoli Malformations of Cortical Development and Epilepsy A. James Barkovich, William B. Dobyns, and Renzo Guerrini mTOR Signaling in Epilepsy: Insights from Malformations of Cortical Development Peter B. Crino Role of Astrocytes in Epilepsy Douglas A. Coulter and Christian Steinhäuser Immunity and Inflammation in Epilepsy Annamaria Vezzani, Bethan Lang, and Eleonora Aronica Neonatal and Infantile Epilepsy: Acquired and Genetic Models Aristea S. Galanopoulou and Solomon L. Moshé Role of Sodium Channels in Epilepsy David I. Kaplan, Lori L. Isom, and Steven Petrou Potassium Channels in Epilepsy Rüdiger Köhling and Jakob Wolfart The Role of Calcium Channels in Epilepsy Sanjeev Rajakulendran and Michael G. Hanna Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channels in Epilepsy Gary P. Brennan, Tallie Z. Baram, and Nicholas P. Poolos GABAergic Synchronization in Epilepsy Roustem Khazipov Glutamatergic Mechanisms Associated with Seizures and Epilepsy Melissa Barker-Haliski and H. Steve White Microcircuits in Epilepsy: Heterogeneity and Hub Cells in Network Synchronization Anh Bui, Hannah K. Kim, Mattia Maroso, and Ivan Soltesz The Diathesis-Epilepsy Model: How Past Events Impact the Development of Epilepsy and Comorbidities Christophe Bernard Single-Gene Determinants of Epilepsy Comorbidity Jeffrey L. Noebels Mechanisms Responsible for Cognitive Impairment in Epilepsy Pierre-Pascal Lenck-Santini and Rodney C. Scott Common Mechanisms Underlying Epileptogenesis and the Comorbidities of Epilepsy Andrey Mazarati and Raman Sankar Epilepsy and Autism Ashura W. Buckley and Gregory L. Holmes Mechanisms of Action of Antiseizure Drugs and the Ketogenic Diet Michael A. Rogawski, Wolfgang Löscher, and Jong M. Rho Interneuron Transplantation as a Treatment for Epilepsy Robert F. Hunt and Scott C. Baraban The Epilepsy Spectrum: Targeting Future Research Challenges Gregory L. Holmes and Jeffrey L. Noebels Index Related Titles Epilepsy: The Biology of a Spectrum Disorder [Hardcover]