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Leukemia and Lymphoma: Molecular & Therapeutic Insights

Book Series:  A Cold Spring Harbor Perspectives in Medicine Collection
Subject Area(s):  Human Biology and DiseaseCancer Biology

Edited by Michael Kharas, Center for Experimental Therapeutics, Sloan Kettering Institute; Ross L. Levine, Memorial Sloan Kettering Cancer Center; Ari M. Melnick, Weill Cornell Medical College, Cornell University

Due November 2020 • 325 pages (approx.), illustrated, index
Hardcover • $135 94.50
ISBN  978-1-621821-42-7
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  •     Description    
  •     Contents    


Leukemia and lymphoma are cancers that affect white blood cells. There are several different types, each with different causes, symptoms, treatments, and survival rates. Acute lymphocytic leukemia (ALL), for example, is the most common childhood cancer, but these diseases can occur in individuals of all ages.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers our current understanding of the molecular underpinnings of leukemia and lymphoma, as well as recent progress in development of therapies that target them. The contributors review the normal functions of hematopoietic stem cells—the precursors to white blood cells—and then examine the genetic, epigenetic, and cellular mechanisms that drive malignant transformation. The roles of clonal hematopoiesis, RNA-binding proteins, and alterations in metabolism and cell signaling (e.g., MAP kinase pathways) are among the topics covered in depth, along with the parts they play in specific types of leukemia and lymphoma.

In addition, the authors discuss state-of-the-art preclinical models of leukemia and lymphoma, existing and prospective therapeutic strategies, and how technologies such as next-generation sequencing have accelerated progress in the field. This volume is therefore a vital reference for all cancer biologists and clinician–scientists concerned with defeating these diseases.


Ross Levine, Ari Melnick, and Michael Kharas
Normal Hematopoiesis Is a Balancing Act of Self-Renewal and Regeneration
Oakley C. Olson, Yoon-A Kang, an Emmanuelle Passegué
Epidemiology and Etiology of Leukemia and Lymphoma
Jordan A. Baeker Bispo, Paulo S. Pinheiro, and Erin K. Kobetz
Impact of Genetics on Mature Lymphoid Leukemias and Lymphomas
Nathanael G. Bailey and Kojo S. Elenitoba-Johnson
Clonal Hematopoiesis and premalignant diseases
Duane Hassane
Cancer Stem Cells
Liran Shlush and Tzah Feldman
Targeting Immunophenotypic Markers on Leukemic Stem Cells: How Lessons From Current Approaches and Advances in the LSC Model Can Inform Better Strategies for Treating AML
Kelly Mitchell and Ulrich Steidl
Pediatric Leukemias and lymphomas
Scott Armstrong
Epigenetics of Leukemia and Lymphomas
Ari Melnick
RNA Regulators in Leukemia and Lymphoma
Michael Kharas
Metabolism of Leukemia and Lymphoma
Andrew Intlekofer
Mouse Models of Myeloid Malignancies
George Vassiliou and Faisal Basheer
Mouse Modeling of Lymphomas
Laura Pasqualucci and Ulf Klein
Modeling Leukemia with Human-Induced Pluripotent Stem Cells
Eirini P. Papapetrou
The Molecular Genetics of Myeloproliferative Neoplasms
Anna E. Marneth an Ann Mullally
Acute Myeloid Leukemia
Ross Levine
Acute Megakaryocytic Leukemia
Maureen McNulty and John D. Crispino
The Genetics and Mechanisms of T-Cell Acute Lymphoblastic Leukemia
Francesca Gianni, Laura Belver, and Adolfo Ferrando
The Biology of B-Progenitor Acute Lymphoblastic Leukemia
Kathryn G. Roberts and Charles G. Mullighan
Chronic Lymphocytic Leukemia
Nicholas Chiorazzi, Shih-Shih Chen, and Kanti R. Rai
Hairy Cell Leukemia and Histiocytic Diseases
Omar Abdel Wahab
Non-Hodgkin Lymphomas: Malignancies Arising from Mature B Cells
Jennifer Shingleton, Jie Wang, Carolyn Baloh, Tushar Dave, Nicholas Davis, Lanie Happ, Othmane Jadi, Rachel Kositsky, Xiang Li, Cassandra Love, Razvan Panea, Qiu Qin, Anupama Reddy, Naina Singhi, Eileen Smith, Devang Thakkar, and Sandeep S. Dave
Mature T-Cell Lymphomas and NK
Teresa Palomero
Plasma Cell Neoplasms
Constantine Mitsiades
Renier Brentjens
Future of New Treatment Paradigms
Ross Levine, Ari Melnick, and Michael Kharas