The PTEN Family

Click to Enlarge				The PTEN Family Book Series: A Cold Spring Harbor Perspectives in Medicine Collection Subject Area(s): Cell Biology; Cancer Biology Edited by Charis Eng, Genomic Medicine Institute, Lerner Research Institute; Joanne Ngeow, National Cancer Centre Singapore; Vuk Stambolic, Princess Margaret Cancer Centre, UHN

				Due January 2020 • 275 pages (approx.), illustrated, index Hardcover • ~~$135~~ 94.50 ISBN 978-1-621823-44-5 You save: 30% You will receive free shipping on this item at checkout. Free shipping offer applies to direct website purchases by individual U.S. and Canada customers only.

Description Contents Description PTEN is an important cellular enzyme that is frequently mutated in cancer. In normal cells, it downregulates signaling though the PI3-kinase pathway that controls cell proliferation. When PTEN is mutated, the PI3 pathway becomes overactive, which can contribute to cancer. This volume examines advances in our understanding of the functions of the PTEN protein, is regulation, and how loss of PTEN can promote the development and progression of different cancers. Contents Preliminary Introduction: PTEN discovery, basic genetics Ramon Parsons Section 1: Structure and Function Structure: Structural Mechanisms of PTEN Regulation Glenn R. Masson and Roger L. Williams PTEN phosphatase activity, lipid, protein Bangyan Stiles Biophysics: Structure with emphasis on the dimerization of PTEN Arne Gericke and Alonzo A. Ross PTEN visualization, localization: Visualization of PTEN conformation changes and implications for disease Mark Scott The Impact of Genetic Variants on PTEN Molecular Functions and Cellular Phenotypes Nicholas Hasle, Kenneth A. Matreyek, and Douglas M. Fowler Section 2: Regulation PTEN nuclear functions Vuk Stambolic The Complex Landscape of Post-Transcriptional PTEN Regulation Erin Sellars, Martino Gabra, and Leonardo Salmena PTEN mouse models of cancer development and progression Pier Paolo Pandolfi PTEN in Regulating Hematopoiesis and Leukemogenesis Yilin Wu, Haichuan Zhu, and Hong Wu Section 3: Signaling pathways PTEN, chromosomes, mitosis: Role of PTEN in mitosis and chromosome stability Wen Shen PTEN and Endocytosis Matthew Lee and Lloyd Trotman PTEN in Chromatin Remodeling Jingyi Yang and Yuxin Yin Section 4: PTEN and Human Disease Human cancer—inherited and sporadic—overview and review of PHTS and PTEN role in sporadic cancers Joanne Ngeow and Charis Eng PTEN in the Stroma Mike Ostrowski and Gustavo Leone Intracellular localization and its functions of PTEN Miho Iijima and Takashi Kato Autism Spectrum Disorder Associated with Germline Heterozygous PTEN Mutations Thomas W. Frazier ASD—mouse models Damon Page PTEN in Autism and Neurodevelopmental Disorders Sebastian Rademacher and Britta J. Eickholt Metabolic Role of PTEN in Insulin Signaling and Resistance Yu Zhe Li, Antonio di Cristofano, and Minna Woo The Role of PTEN in Innate and Adaptive Immunity Henry Taylor, Arian Laurence, and Holm H. Uhlig PTEN diagnostics: A systems pathology approach Deborah Marsh Precise immunodetection of PTEN protein in human neoplasia Rafael Pulido, Janire Mingo, Ayman Gaafar, Caroline E. Nunes-Xavier, Sandra Luna, Leire Torices, Javier C. Angulo, and José I. López Index

The PTEN Family

Description

Contents