DNA Recombination

Click to Enlarge				DNA Recombination Book Series: A Cold Spring Harbor Perspectives in Biology Collection Subject Area(s): Molecular Biology; Biochemistry Edited by Stephen Kowalczykowski, PhD, University of California, Davis; Neil Hunter, PhD, University of California, Davis; Wolf-Dietrich Heyer, PhD, University of California, Davis *Download a Free Excerpt from DNA Recombination:* Preface Index

				© 2016 • 549 pages, illustrated (87 color, 9 B&W), index Hardcover • ~~$135~~ 94.50 ISBN 978-1-621820-09-3 You save: 30% You will receive free shipping on this item at checkout. Free shipping offer applies to direct website purchases by individual U.S. and Canada customers only.

Description Contents Description Homologous recombination involves the precise exchange of similar or identical nucleic acid sequences between two DNA molecules. This process directs the repair of many DNA lesions in somatic cells and generates genetic variation in sperm and egg cells during meiosis. It is a nearly universal biological process that is conserved from phage to humans. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers all aspects of recombinational DNA repair, meiotic recombination, and the regulation of these processes. The contributors examine the dozens of proteins that are involved in recombinational repair and the various pathways in which they are employed (e.g., gene conversion or break-induced replication). They also discuss how these proteins and pathways are strictly regulated to avoid genomic instability, which can lead to diseases such as cancer, and how they are coordinated with other nuclear processes (e.g., transcription and DNA replication). Meiotic recombination, the characteristics that distinguish it from recombinational repair, and effects of its dysregulation (e.g., aneuploidy) are also covered in depth. This volume is an indispensable reference for biochemists, molecular biologists, and cell biologists who want to understand how DNA recombination maintains genomic integrity in individual organisms and across generations. Contents Preface PART 1: MECHANISMS OF RECOMBINATION An Overview of the Molecular Mechanisms of Recombinational DNA Repair Stephen C. Kowalczykowski Sources of DNA Double-Strand Breaks and Models of Recombinational DNA Repair Anuja Mehta and James E. Haber End Resection at Double-Strand Breaks: Mechanism and Regulation Lorraine S. Symington DNA-Pairing and Annealing Processes in Homologous Recombination and Homology-Directed Repair Scott W. Morrical Mediators of Homologous DNA Pairing Alex Zelensky, Roland Kanaar, and Claire Wyman Regulation of DNA Pairing in Homologous Recombination James M. Daley, William A. Gaines, YoungHo Kwon, and Patrick Sung The Dissolution of Double Holliday Junctions Anna H. Bizard and Ian D. Hickson Holliday Junction Resolvases Haley D.M. Wyatt and Stephen C. West Structural Studies of DNA End Detection and Resection in Homologous Recombination Christian Bernd Schiller, Florian Ulrich Seifert, Christian Linke-Winnebeck, and Karl-Peter Hopfner PART 2: REGULATION OF RECOMBINATION AND GENOMIC MAINTENANCE Regulation of Recombination and Genomic Maintenance Wolf-Dietrich Heyer Cell Biology of Mitotic Recombination Michael Lisby and Rodney Rothstein Transcription and Recombination: When RNA Meets DNA Andrés Aguilera and Hélène Gaillard Recombination and Replication Aisha H. Syeda, Michelle Hawkins, and Peter McGlynn Mismatch Repair during Homologous and Homeologous Recombination Maria Spies and Richard Fishel The Role of Double-Strand Break Repair Pathways at Functional and Dysfunctional Telomeres Ylli Doksani and Titia de Lange Mechanisms of Gene Duplication and Amplification Andrew B. Reams and John R. Roth Homologous Recombination and Human Health: The Roles of BRCA1, BRCA2, and Associated Proteins Rohit Prakash, Yu Zhang, Weiran Feng, and Maria Jasin PART 3: MEIOTIC RECOMBINATION Meiotic Recombination: The Essence of Heredity Neil Hunter Recombination, Pairing, and Synapsis of Homologs during Meiosis Denise Zickler and Nancy Kleckner Mechanism and Regulation of Meiotic Recombination Initiation Isabel Lam and Scott Keeney Initiation of Meiotic Homologous Recombination: Flexibility, Impact of Histone Modifications, and Chromatin Remodeling Lóránt Székvölgyi, Kunihiro Ohta, and Alain Nicolas DNA Strand Exchange and RecA Homologs in Meiosis M. Scott Brown and Douglas K. Bishop The Meiotic Checkpoint Network: Step-by-Step through Meiotic Prophase Vijayalakshmi V. Subramanian and Andreas Hochwagen Meiosis and Maternal Aging: Insights from Aneuploid Oocytes and Trisomy Births Mary Herbert, Dimitrios Kalleas, Daniel Cooney, Mahdi Lamb, and Lisa Lister Index

DNA Recombination

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