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Metastasis: Mechanism to Therapy

Nearly all types of cancer have the ability to metastasize, or spread from one organ or tissue in the body to another. Metastatic disease is responsible for the majority of cancer deaths and, therefore, is a critical area of research. Work to better understand the metastatic cascade—how cells detach from a primary tumor, migrate through the body, and seed secondary tumors at distant locations—will lead to improved treatment options for patients with cancer.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers the recent progress that has been made in understanding the molecular mechanisms underlying metastasis and how this knowledge is paving the way for new therapeutic targets. The contributors discuss progress in defining mutations that might be driving metastasis, the formation of a premetastatic niche and how it enhances the establishment of a secondary tumor, and how changes that occur during aging increase the metastatic capacity of tumor cells. They also consider the selection and colonization of common target organs (e.g., brain, liver, and bones) during metastasis and the roles of immune cells and extracellular vesicles at different steps of the metastatic cascade. Cellular plasticity—including evidence for metastatic stem cells and the role of tumor cell dormancy in recurrent metastasis—is also covered.

In addition, the authors describe the development of in vivo models and techniques for studying metastasis, methods for monitoring tumor progression and metastatic spread (e.g., intravital microscopy and liquid biopsy), and immunotherapies that can potentially target cancer metastasis. This volume is therefore a vital reference for all cancer biologists and clinician-scientists concerned with defeating cancer.

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Preface
Normal Aging and Its Role in Cancer Metastasis
Index

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Description
Contents
   

© 2020 • 326 pages, illustrated (45 color), index
Hardcover • $75.00 • ISBN 978-1-621823-24-7


 

Description

Nearly all types of cancer have the ability to metastasize, or spread from one organ or tissue in the body to another. Metastatic disease is responsible for the majority of cancer deaths and, therefore, is a critical area of research. Work to better understand the metastatic cascade—how cells detach from a primary tumor, migrate through the body, and seed secondary tumors at distant locations—will lead to improved treatment options for patients with cancer.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers the recent progress that has been made in understanding the molecular mechanisms underlying metastasis and how this knowledge is paving the way for new therapeutic targets. The contributors discuss progress in defining mutations that might be driving metastasis, the formation of a premetastatic niche and how it enhances the establishment of a secondary tumor, and how changes that occur during aging increase the metastatic capacity of tumor cells. They also consider the selection and colonization of common target organs (e.g., brain, liver, and bones) during metastasis and the roles of immune cells and extracellular vesicles at different steps of the metastatic cascade. Cellular plasticity—including evidence for metastatic stem cells and the role of tumor cell dormancy in recurrent metastasis—is also covered.

In addition, the authors describe the development of in vivo models and techniques for studying metastasis, methods for monitoring tumor progression and metastatic spread (e.g., intravital microscopy and liquid biopsy), and immunotherapies that can potentially target cancer metastasis. This volume is therefore a vital reference for all cancer biologists and clinician-scientists concerned with defeating cancer.

 
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Contents

Preface
Cancer Cell Dormancy in Metastasis
Matthew A. Summers, Michelle M. McDonald, and Peter I. Croucher
Premetastasis
Yoshiro Maru
Brain Metastasis Organotropism
Arseniy E. Yuzhalin and Dihua Yu
Bone Tropism in Cancer Metastases
Hai Wang, Weijie Zhang, Igor Bado, and Xiang H.-F. Zhang
Liver Tropism in Cancer: The Hepatic Metastatic Niche
Ainhoa Mielgo and Michael C. Schmid
Normal Aging and Its Role in Cancer Metastasis
Mitchell Fane and Ashani T. Weeraratna
The Immune Microenvironment and Cancer Metastasis
Asmaa El-Kenawi, Kay Hänggi, and Brian Ruffell
Myeloid Cells in Metastasis
Agnieszka Swierczak and Jeffrey W. Pollard
Impact of Immunometabolism on Cancer Metastasis: A Focus on T Cells and Macrophages
Nina C. Flerin, Sotiria Pinioti, Alessio Menga, Alessandra Castegna, and Massimiliano Mazzone
Extracellular Vesicles and Metastasis
Shizhen Emily Wang
Cancer Stem Cells and Epithelial-to-Mesenchymal Transition in Cancer Metastasis
Toni Celià-Terrassa and Mohit Kumar Jolly
Clinical Perspectives in Brain Metastasis
Krutika Deshpande, Ian Buchanan, Vahan Martirosian, and Josh Neman
New Approaches on Cancer Immunotherapy
Jong-Ho Cha, Li-Chuan Chan, Min Sup Song, and Mien-Chie Hung
The Etiology and Impact of Muscle Wasting in Metastatic Cancer
Anup K. Biswas and Swarnali Acharyya
The Different Facets of Liquid Biopsy: A Kaleidoscopic View
Zahra Eslami-S, Luis Enrique Cortés-Hernández, Laure Cayrefourcq, and Catherine Alix-Panabières
Zebrafish In Vivo Models of Cancer and Metastasis
Katy R. Astell and Dirk Sieger
Cellular Plasticity during Metastasis: New Insights Provided by Intravital Microscopy
Andreia S. Margarido, Laura Bornes, Claire Vennin, and Jacco van Rheenen
Index
 

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Metastasis: Mechanism to Therapy