© 2021 • 749 pages, illustrated (111 color and 4 B&W), index
Hardcover • $75.00 • ISBN 978-1-621823-07-0

Influenza is a serious infectious disease caused by different influenza viruses that can mutate to form new strains. Some of these strains give rise to epidemics or pandemics, infecting millions worldwide each year. Because evolutionary changes in these viruses are difficult to predict and our understanding of their pathogenic effects is incomplete, the development of effective vaccines and therapeutics for influenza remains challenging.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine reviews cutting-edge research on the viruses that cause influenza, the molecular mechanisms of infection, the epidemiology of these viruses in humans and animals, and current strategies for designing vaccines and antivirals. Contributors discuss all aspects of the molecular virology of influenza—the viral and host factors involved in the attachment and entry into host cells, the transcription and replication of viral genomes, and virus assembly and budding. The various factors and conditions that determine susceptibility to influenza infection and disease severity are also covered, as is our current understanding of the ecology and evolution of influenza viruses, the various subtypes, and their transmission and epidemiology in humans, birds, swine, bats, and other animals.

In addition, the authors examine the human immune response to influenza infection, insights gained from animal models, and technological advances in the design and delivery of vaccines and antivirals. This volume is therefore an essential reference for all virologists, clinical and laboratory investigators, and physicians interested in reducing the global public health burden of influenza.

Preface

VIROLOGY

Structure and Function of the Influenza Virus Transcription and Replication Machinery

Ervin Fodor and Aartjan J.W. te Velthuis

Structure and Function of Influenza Polymerase

Joanna M. Wandzik, Tomas Kouba, and Stephen Cusack

Hemagglutinin Structure and Activities

Steven J. Gamblin, Sébastien G. Vachieri, Xiaoli Xiong, Jie Zhang, Stephen R. Martin, and John J. Skehel

Influenza Hemagglutinin Structures and Antibody Recognition

Nicholas C. Wu and Ian A. Wilson

The Structure, Function, and Pathobiology of the Influenza A and B Virus Ion Channels

Robert A. Lamb

Accessory Gene Products of Influenza AVirus

Rute M. Pinto, Samantha Lycett, Eleanor Gaunt, and Paul Digard

Selective Genome Packaging Mechanism of Influenza A Viruses

Takeshi Noda

Host Cell Factors That Interact with Influenza Virus Ribonucleoproteins

Ecco Staller and Wendy S. Barclay

The Two Sides of the Same Coin—Influenza Virus and Intracellular Signal Transduction

Stephan Ludwig, Eike R. Hrincius, and Yvonne Boergeling

Experimental Approaches to Identify Host Factors Important for Influenza Virus

Grace A. Schaack and Andrew Mehle

Synthetic Virology: Building Viruses to Better Understand Them

Benjamin R. tenOever

Quantifying Between-Host Transmission in Influenza Virus Infections

Katherine E.E. Johnson and Elodie Ghedin

The Ecology and Evolution of Influenza Viruses

Michelle Wille and Edward C. Holmes

Influenza Reverse Genetics—Historical Perspective

Gabriele Neumann

INFLUENZA IN HUMANS

The 1918 Influenza Pandemic and Its Legacy

Jeffery K. Taubenberger and David M. Morens

Human Susceptibility to Influenza Infection and Severe Disease

Robert C. Mettelman and Paul G. Thomas

Influenza in Children

Jennifer Nayak, Gregory Hoy, and Aubree Gordon

Influenza in High-Risk Hosts—Lessons Learned from Animal Models

Rebekah Honce, Nicholas Wohlgemuth, Victoria A. Meliopoulos, Kirsty R. Short, and Stacey Schultz-Cherry

Human Influenza Epidemiology

Sukhyun Ryu and Benjamin J. Cowling

The Epidemiology, Virology, and Pathogenicity of Human Infections with Avian Influenza Viruses

Dayan Wang, Wenfei Zhu, Lei Yang, and Yuelong Shu

INFLUENZA IN ANIMALS

Emerging HxNy Influenza AViruses

William J. Liu, Yan Wu, Yuhai Bi, Weifeng Shi, Dayan Wang, Yi Shi, and George F. Gao

H5 Influenza Viruses in Egypt

Rabeh El-Shesheny, Ahmed Kandeil, Ahmed Mostafa, Mohamed A. Ali, and Richard J. Webby

H7N9 Influenza Virus in China

Chengjun Li and Hualan Chen

H9 Influenza Viruses: An Emerging Challenge

Silvia Carnaccini and Daniel R. Perez

Pathobiological Origins and Evolutionary History of Highly Pathogenic Avian Influenza Viruses

Dong-Hun Lee, Miria Ferreira Criado, and David E. Swayne

Swine Influenza AViruses and the Tangled Relationship with Humans

Tavis K. Anderson, Jennifer Chang, Zebulun W. Arendsee, Divya Venkatesh, Carine K. Souza, J. Brian Kimble, Nicola S. Lewis, C. Todd Davis, and Amy L. Vincent

Equine Influenza

Thomas M. Chambers

Canine and Feline Influenza

Brian R. Wasik, Ian E.H. Voorhees, and Colin R. Parrish

Bat-Borne Influenza AViruses: An Awakening

Kevin Ciminski and Martin Schwemmle

Ferreting Out Influenza Virus Pathogenicity and Transmissibility: Past and Future Risk Assessments in the Ferret Model

Jessica A. Belser, Joanna A. Pulit-Penaloza, and Taronna R. Maines

IMMUNOLOGY

Original Antigenic Sin: How Original? How Sinful?

Jonathan W. Yewdell and Jefferson J.S. Santos

Influenza Vaccines Delivered in Early Childhood Could Turn Antigenic Sin into Antigenic Blessings

Michael Worobey, Stanley Plotkin, and Scott E. Hensley

Immunity to Influenza Infection in Humans

David J. Topham, Marta L. DeDiego, Aitor Nogales, Mark Y. Sangster, and Andrea Sant

Influenza Immunization in the Context of Preexisting Immunity

Susanne L. Linderman, Ali H. Ellebedy, Carl Davis, Christiane S. Eberhardt, Rustom Antia, Rafi Ahmed, and Veronika I. Zarnitsyna

Induction and Evasion of Type-I Interferon Responses during Influenza A Virus Infection

Raquel Muñoz-Moreno, Carles Martínez-Romero, and Adolfo García-Sastre

Systems Biological Analysis of Immune Response to Influenza Vaccination

Mario Cortese, Amy C. Sherman, Nadine G. Rouphael, and Bali Pulendran

VACCINES AND ANTIVIRALS

Next-Generation Influenza Vaccines

Masaru Kanekiyo and Barney S. Graham

Influenza Vaccine Effectiveness: New Insights and Challenges

Huong Q. McLean and Edward A. Belongia

Live Attenuated Cold-Adapted Influenza Vaccines

Kanta Subbarao

Influenza Therapeutics in Clinical Practice—Challenges and Recent Advances

John H. Beigel and Frederick G. Hayden

Influenza Polymerase Inhibitors: Mechanisms of Action and Resistance

Emi Takashita

Antivirals Targeting the Neuraminidase

Larisa Gubareva and Teena Mohan

Index