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Subject Area(s):  Neurobiology

Edited by Ben A. Barres, Stanford University School of Medicine; Marc R. Freeman, Howard Hughes Medical Institute, University of Massachusetts Medical School; Beth Stevens, Boston Children's Hospital, Harvard University

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Preface and Contents

© 2015 • 486 pages, illustrated (83 color, 3 B&W), index
Hardcover • $135 94.50
ISBN  978-1-621820-27-7
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  •     Description    
  •     Contents    


The majority of cells in the nervous system are glia. Long thought of as passive bystanders, glial cells are increasingly being appreciated for their active roles in nervous system development, function, and disease.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology examines the development of the major classes of glial cells—astrocytes, oligodendrocytes, Schwann cells, and microglia—and their roles in normal physiology and disease. The contributors describe how glia help establish and refine synaptic connections, maintain the metabolic and ionic milieu of nerve cells, myelinate axons, modulate nerve signal propagation, and contribute to the blood–brain barrier. The biological characteristics of glial cells in vertebrate and invertebrate model systems, including those of Drosophila, Caenorhabditis elegans, and zebrafish, are also covered.

The authors also discuss the roles of glia in repair and regeneration, as well as in cancer and neurodegenerative diseases. This volume is therefore a valuable reference for all neurobiologists and biomedical scientists wishing to understand these diverse and dynamic cells.


Astrocyte Development and Heterogeneity
Omer Ali Bayraktar, Luis C. Fuentealba, Arturo Alvarez-Buylla, and David H. Rowitch
Astrocytes Control Synapse Formation, Function, and Elimination
Won-Suk Chung, Nicola J. Allen, and Cagla Eroglu
Astrocyte Regulation of Blood Flow in the Brain
Brian A. MacVicar and Eric A. Newman
The Astrocyte: Powerhouse and Recycling Center
Bruno Weber and L. Felipe Barros
Astrocyte Calcium Signaling: From Observations to Functions and the Challenges Therein
Baljit S. Khakh and Ken D. McCarthy
The Blood-Brain Barrier
Richard Daneman and Alexandre Prat
Michael V Sofroniew
How Do Astrocytes Participate in Neural Plasticity?
Philip G. Haydon and Maiken Nedergaard
Oligodendrocyte Development and Plasticity
Dwight E. Bergles and William D. Richardson
Transcriptional and Epigenetic Regulation of Oligodendrocyte Development and Myelination in the Central Nervous System
Ben Emery and Q. Richard Lu
Oligodendrocytes: Myelination and Axonal Support
Mikael Simons and Klaus-Armin Nave
Schwann Cells: Development and Role in Nerve Repair
Kristján R. Jessen, Rhona Mirsky, and Alison C. Lloyd
The Nodes of Ranvier: Molecular Assembly and Maintenance
Matthew N. Rasband and Elior Peles
Perisynaptic Schwann Cells at the Neuromuscular Synapse: Adaptable, Multitasking Glial Cells
Chien-Ping Ko and Richard Robitaille
Perineurial Glia
Sarah Kucenas
Schwann Cell Myelination
James L. Salzer
Origin of Microglia: Current Concepts and Past Controversies
Florent Ginhoux and Marco Prinz
Microglia Function in Central Nervous System Development and Plasticity
Dorothy P. Schafer and Beth Stevens
Microglia in Health and Disease
Richard M. Ransohoff and Joseph El Khoury
Drosophila Central Nervous System Glia
Marc R. Freeman
Glial Development and Function in the Nervous System of Caenorhabditis elegans
Shai Shaham
Glial Cell Development and Function in Zebrafish
David A. Lyons and William S. Talbot
Glia Disease and Repair—Remyelination
Robin J.M. Franklin and Steven A. Goldman
Central Nervous System Regenerative Failure: Role of Oligodendrocytes, Astrocytes, and Microglia
Jerry Silver, Martin E. Schwab, and Phillip G. Popovich
Cell of Origin for Malignant Gliomas and Its Implication in Therapeutic Development
Hui Zong, Luis F. Parada, and Suzanne J. Baker
Astrocytes in Neurodegenerative Disease
Hemali Phatnani and Tom Maniatis